Lipids & metabolic liver disease
Atherogenic index of plasma and coronary artery disease: a systematic review and meta-analysis of observational studies
Pooled result · CADResult — go to the resultOdds ratio 2.79 95% CI 1.75–4.45Authors' conclusion
This meta-analysis demonstrates that elevated AIP is strongly associated with increased CAD risk, greater severity, and poorer prognosis in populations with and without established CAD. However, more studies are needed to evaluate the predictive performance and determine the optimal cut-off for AIP in different populations.
Study context
- Population
- Populations with and without established coronary artery disease (CAD); cross-sectional, case-control and cohort studies (PubMed, Embase, Web of Science to August 13, 2024)51 observational studies
- Comparison
- Higher vs lower atherogenic index of plasma (AIP)
- Outcome
- Relationship between AIP and CAD risk, severity and prognosis
Methodological detailsrandom-effects model, multivariate analysis
- Random-effects model
- Multivariate analysis
Pooled result
CAD
Odds ratio
2.79
95% CI 1.75–4.45
P < 0.00001
Higher AIPvs Lower AIP
OR 2.79 (95% CI 1.75–4.45); P < 0.00001
As reported in the abstract
Further pooled results
| Outcome | Estimate | P value | |
|---|---|---|---|
| Coronary artery calcificationHigher AIPvs Lower AIP | OR 2.28 (95% CI 1.74–3.00) | P < 0.00001 | |
| Multivessel CADHigher AIPvs Lower AIP | OR 2.04 (95% CI 1.50–2.77) | P < 0.00001 | |
| Plaque progressionHigher AIPvs Lower AIP | OR 1.49 (95% CI 1.17–1.91) | P = 0.001 | |
| MACE, populations without established CADHigher AIPvs Lower AIP | HR 1.28 (95% CI 1.22–1.35) | P < 0.00001 | |
| MACE, acute coronary syndromeHigher AIPvs Lower AIP | HR 1.59 (95% CI 1.33–1.89) | P < 0.00001 | |
| MACE, chronic coronary syndrome or stable CADHigher AIPvs Lower AIP | HR 1.65 (95% CI 1.15–2.37) | P = 0.007 | |
| 0.20.5125Ratio (log scale) |
Original publication
Atherogenic index of plasma and coronary artery disease: a systematic review and meta-analysis of observational studies. Cardiovasc Diabetol. Published 22 January 2025. doi:10.
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