Lipids & metabolic liver disease
Association between atherogenic index of plasma and future risk of cardiovascular disease in individuals with cardiovascular-kidney-metabolic syndrome stages 0–3: a nationwide prospective cohort study
Authors' conclusion
Poor control level of AIP are associated with an increased risk of CVD events in the population of CKM stages 0-3. Long-term dynamic monitoring of changes in AIP may help in the early identification of patients at high risk of developing CVD in the individuals with CKM stages 0-3.
Study context
- Population
- Individuals with cardiovascular-kidney-metabolic syndrome stages 0–3, China Health and Retirement Longitudinal Study (CHARLS)
- Participants
- 3,429 individuals
- Exposure
- Atherogenic Index of Plasma (AIP) control classes vs best AIP control class 1
- Outcome
- Incident CVD (self-reported heart disease and/or stroke)
- Follow-up
- 3-year follow-up
Methodological detailsnationwide
- Nationwide
Main finding
As reported in the abstract
Incident CVD
Each group vs class 1Odds ratio (95% CI)
Class 2
1.37(1.04–1.81)
Class 3
1.54(1.04–2.26)
Class 4
1.65(1.13–2.41)
Class 5
2.14(1.15–3.97)
- Participants developing cardiovascular disease (CVD)
- 620
Observational data: associations, not effects.
Further findings
Shape of AIP–CVD association (RCS)
- Changes in AIP were linearly associated with occurrence of CVD events
Key AIP component predicting CVD
- Triglyceride (TG) was a key variable for AIP in predicting CVD events (weighted quartiles and regression analyses)
Original publication
Association between atherogenic index of plasma and future risk of cardiovascular disease in individuals with cardiovascular-kidney-metabolic syndrome stages 0–3: a nationwide prospective cohort study. Cardiovasc Diabetol. Published 18 January 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →