Maturity-Onset Diabetes of the Young (MODY) in a Racially/Ethnically Diverse Pediatric Population
Authors' conclusion
The current guidelines to consider a diagnosis of MODY may not apply to a racially/ethnically diverse US population of children with diabetes.
Study context
- Population
- Racially/ethnically diverse youth with genetically confirmed MODY, large academic pediatric hospital, Southwestern USgenetically confirmed MODY
- Participants
- 50 participants
- Exposure
- GCK-MODY vs HNF1A-MODY vs HNF1B-MODY vs HNF4A-MODY vs Dual molecular diagnosis
- GCK-MODYn = 30
- HNF1A-MODYn = 8
- HNF1B-MODYn = 9
- HNF4A-MODYn = 2
- Dual molecular diagnosisn = 1
- Outcome
- Features of MODY cases vs guideline criteria
Methodological detailssingle-centre, genetically confirmed cases
- Single-centre
- Genetically confirmed cases
Main finding
As reported in the abstract
- Race/ethnicity other than non-Hispanic White
- 52% (n = 26)
- Lack of parental diabetes history
- 24% (n = 12)
- Obesity/overweight at diagnosis
- 22.2% (n = 11)
- Dyslipidemia and/or hypertension
- 30% (n = 15)
- Acanthosis nigricans on physical examination
- 12% (n = 6)
- Islet antibody positivity in GCK-MODY
- 8% (n = 4)
Observational data: associations, not effects.
Further findings
Mean HbA1c at diabetes diagnosis — HNF4A-MODY, HNF1A-MODY, HNF1B-MODY vs GCK-MODY · higher in HNF4A-, HNF1A- and HNF1B-MODY
P = 0.005
Original publication
Maturity-Onset Diabetes of the Young (MODY) in a Racially/Ethnically Diverse Pediatric Population. J Clin Endocrinol Metab. Published 24 June 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →