Objective and Subjective Sleep Patterns in Adults With Maturity-Onset Diabetes of the Young (MODY)
Authors' conclusion
Sleep disturbances appear to be common in adults with MODY despite absent traditional risk factors for sleep disorders. Future research investigating the sleep-diabetes relationship is warranted in this population.
Study context
- Population
- Adults with GCK-MODY and transcription factor (TF)-related MODY from The University of Chicago's Monogenic Diabetes Registry; age 46.0 years, 79% women, BMI 24.7 kg/m²
- Participants
- 24 adults
- Exposure
- GCK-MODY vs TF-related MODY
- Outcome
- Sleep patterns by 2-week wrist actigraphy (315 nights), one-night home sleep apnea test and validated surveys
Methodological detailssingle-registry recruitment, wrist actigraphy, home sleep apnea test
- Single-registry recruitment
- Wrist actigraphy
- Home sleep apnea test
Main finding
As reported in the abstract
Sleep patterns, all participants
- Sleep latency ≥15 min
- 29%
- Sleep efficiency ≤85%
- 38%
- Wake after sleep onset >40 min
- 46%
- Sleep duration <7 h
- 54%
- Reported poor sleep quality
- 88%
- Obstructive sleep apnea
- 58%
- Reported insomnia
- 71%
Observational data: associations, not effects.
Further findings
Objective sleep quality and night-to-night variability by MODY type
- TF-related MODY had poorer objective sleep quality and increased night-to-night variability in sleep patterns vs GCK-MODY
Original publication
Objective and Subjective Sleep Patterns in Adults With Maturity-Onset Diabetes of the Young (MODY). Diabetes Care. Published 13 January 2023. doi:10.
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