Rural Residence Is Associated With a Delayed Trend Away From Sulfonylurea Use for Treatment Intensification of Type 2 Diabetes
Main finding · SU use at treatment intensification (adjusted)Result — go to the resultAdjusted odds ratio 1.34 95% CI 1.29–1.39Authors' conclusion
Variation in sulfonylurea dispensation across the rural-urban continuum provides a basis for continued research in the differences in process of care by location.
Study context
- Population
- Adult new metformin users, April 2008–March 2019, Alberta, Canada; at treatment intensification mean age 55 years, 62% male, 27% rural residents66,084 intensified
- Participants
- 171,759 users
- Exposure
- Rural vs urban vs metropolitan residence
- Outcome
- SU-based treatment intensification
Methodological detailsadministrative health records, multivariable logistic regression
- Administrative health records
- Multivariable logistic regression
Main finding
SU use at treatment intensification (adjusted)
Adjusted odds ratio
1.34
95% CI 1.29–1.39
As reported in the abstract
Observational data: associations, not effects.
Further findings
SU dispensed at first treatment intensification · beginning of observation period — between Rural and Urban · across rural, urban and metropolitan
P = 0.009
SU users at treatment intensification · later in observation period — between Rural and Urban · across rural, urban and metropolitan
P < 0.001
- SU users at treatment intensification — Trend away from SU use delayed for rural residents
- ∼4 years
Treatment intensification (all new metformin users) · mean 1.5 years
- Treatment intensified
- 66,084 (38%)
- SU as most common drug for intensification
- 30,297 (46%)
Original publication
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