Serum Mac-2 Binding Protein Glycosylation Isomer Concentrations Are Associated With Incidence of Type 2 Diabetes
Authors' conclusion
The present study demonstrated that higher serum M2BPGi concentrations were significantly associated with higher risk of diabetes in a Japanese community. Moreover, inflammation and insulin resistance were suggested to contribute to the excess risk of diabetes in individuals with higher serum M2BPGi levels. These findings shed light on the importance of inflammation and insulin resistance when considering the pathogenesis of diabetes.
Study context
- Population
- Community-dwelling Japanese individuals aged 40–79 years without diabetes at baseline
- Participants
- 2,143 individuals
- Exposure
- Serum M2BPGi quintiles
- Outcome
- Development of T2D
- Follow-up
- 7 years
Methodological detailscommunity-based, 7-year follow-up
- Community-based
- 7-year follow-up
Main finding
As reported in the abstract
Incidence of T2D across M2BPGi quintiles · 7-year follow-up
- Individuals who developed T2D
- 219
- Age- and sex-adjusted cumulative incidence of T2D increased with higher M2BPGi
- P for trend < .01
- Association remained significant after adjustment for potential confounders
- P for trend = .04
Observational data: associations, not effects.
Original publication
Serum Mac-2 Binding Protein Glycosylation Isomer Concentrations Are Associated With Incidence of Type 2 Diabetes. J Clin Endocrinol Metab. Published 13 January 2023. doi:10.
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