Associations of diabetes status and physical activity with cognitive impairment and hippocampal volume in older adults
Main finding · Cognitive impairment (Montreal Cognitive Assessment score ≤22)Result — go to the resultOdds ratio 2.51 95% CI 1.40–4.49Authors' conclusion
Individuals with both DM and low PA had the highest prevalence of cognitive impairment and lower hippocampal volume. Neither interaction reached statistical significance; however, a moderate interaction for cognitive impairment could not be excluded, and the hippocampal findings should be interpreted cautiously.
Study context
- Population
- Community-dwelling older adults, Bunkyo Health Study; mean age 73.1 ± 5.4 years, 57.7% women
- Participants
- 1,615 adults
- Exposure
- Diabetes mellitus (DM) status and physical activity (PA) level
- Outcome
- Cognitive impairment (Montreal Cognitive Assessment score ≤22)
Main finding
As reported in the abstract
Odds ratio
2.51
95% CI 1.40–4.49
By group
DM/low PAvs non-DM/high PA
OR 2.51 (95% CI 1.40–4.49)
Observational data: associations, not effects.
Further findings
Hippocampal volume (0.3-T MRI), adjusted
- Adjusted hippocampal volume lower in DM/low PA than in the non-DM groups
- DM × PA interaction did not reach statistical significance
Original publication
Associations of diabetes status and physical activity with cognitive impairment and hippocampal volume in older adults. J Clin Endocrinol Metab. Published 31 August 2026. doi:10.
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