Associations of C-reactive protein–triglyceride glucose-related indices with mortality across glycemic states: a nationwide prospective cohort study
Authors' conclusion
Several CTI-related indices were associated with mortality within glycemic-status strata. However, the findings do not establish effect modification, group-specific applicability, or validated clinical utility.
Study context
- Population
- Adults from the 1999–2010 and 2015–2018 National Health and Nutrition Examination Survey
- Participants
- 13,867 adults
- Exposure
- CTI-related indices and mortality within glycemic-status strata
- Outcome
- All-cause and cardiovascular mortality
Methodological detailsnationwide, complex-survey weighted Cox models
- Nationwide
- Complex-survey weighted Cox models
Main finding
As reported in the abstract
Hazard ratio (95 % CI)
CTI-ABSIper weighted SD; all-cause mortality
1.21(1.10–1.34)
CTI-ABSIper weighted SD; cardiovascular mortality
1.43(1.18–1.73)
CTI-WWIper weighted SD; all-cause mortality
1.19(1.07–1.33)
CTI-WWIper weighted SD; cardiovascular mortality
1.49(1.20–1.85)
Per weighted SD, as printed
Observational data: associations, not effects.
Further findings
Discrimination (time-dependent ROC)
- CTI-ABSI and CTI-WWI had relatively higher single-marker AUCs in several analyses, but incremental improvements beyond clinical factors were small
Glycemic-status interaction
- Glycemic-status interactions were not statistically significant
Original publication
Associations of C-reactive protein–triglyceride glucose-related indices with mortality across glycemic states: a nationwide prospective cohort study. Diabetes Res Clin Pract. Published 30 August 2026. doi:10.
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