The C-reactive protein-triglyceride-glucose index and its obesity-derived indicators predict cardio-renal-metabolic multimorbidity: evidence from the UK biobank and CHARLS
Authors' conclusion
CTI-derived obesity-related indices, especially CTI-WC and CTI-WHtR, were associated with CRMM incidence and progression and may improve risk stratification.
Study context
- Population
- Participants from UK Biobank and CHARLS; CRMM defined as coexistence of CVD, T2D and CKD374,513 UK Biobank
- Exposure
- C-reactive protein-triglyceride glucose index (CTI) and its five obesity-derived indices and CRMM risk
- Outcome
- Incident CRMM and disease transitions
- Follow-up
- 15.98 years
Methodological detailstwo cohorts (UK Biobank and CHARLS), Cox, RCS and multistate models
- Two cohorts (UK Biobank and CHARLS)
- Cox, RCS and multistate models
Main finding
As reported in the abstract
Incident CRMM (UK Biobank) · 15.98 years
Hazard ratio (95% CI)
CTI-WCstrongest association
1.974(1.943–2.007)
CTI-WHtR
1.919(1.890–1.950)
- Developed CRMM
- 13,315 participants
Observational data: associations, not effects.
Further findings
Transition from healthy to FCRMD (multistate analysis)
| HR (95% CI) | ||
|---|---|---|
| CTI-WC | 1.538 (1.526–1.550) | |
| 0.512Hazard ratio (log scale) |
Added predictive value of CTI-derived indices
- NRI
- 21.161% to 23.929%
- IDI
- 1.051% to 1.512%
- ΔC-index
- 0.029 to 0.038
CHARLS validation
- Associations directionally consistent but attenuated
Original publication
The C-reactive protein-triglyceride-glucose index and its obesity-derived indicators predict cardio-renal-metabolic multimorbidity: evidence from the UK biobank and CHARLS. Diabetes Res Clin Pract. Published 1 August 2026. doi:10.
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