Early detection of type 2 diabetes mellitus‐associated cognitive dysfunction: The potential of amide proton transfer‐weighted imaging
Authors' conclusion
APTw imaging suggested a spatially evolving pattern of hippocampal damage in T2DM, where the left body may show early alterations, with the left head potentially becoming more implicated upon MCI onset. These findings provide preliminary evidence supporting the potential of APTw as an early, non-invasive biomarker for tracking neuropathological progression in DACD.
Study context
- Population
- T2DM patients with and without MCI and community-based controls without MCI27 T2DM patients
- Participants
- 19 / 8 / 11
- Comparison
- T2DM-MCI vs T2DM-nMCI vs CG-nMCI
- T2DM-MCIn = 19
- T2DM-nMCIn = 8
- CG-nMCIn = 11reference
- Outcome
- Diagnostic performance of hippocampal APTw SI
Performance
As reported in the abstract
| Test or model | AUC (left hippocampal body) | AUC (left hippocampal head) |
|---|---|---|
| T2DM-nMCI | 0.793 | — not stated in the abstract |
| T2DM-MCI | — not stated in the abstract | 0.732 |
AUC (left hippocampal body)
T2DM-nMCI0.793
T2DM-MCI— not stated in the abstract
AUC (left hippocampal head)
T2DM-nMCI— not stated in the abstract
T2DM-MCI0.732
— not stated in the abstract
- Left hippocampal body AUC for T2DM-nMCI
- P = 0.045
- Left hippocampal head AUC for T2DM-MCI
- P = 0.034
Further findings
Correlation of left hippocampal head amide proton transfer-weighted (APTw) signal intensity (SI) with cognitive scores in T2DM-nMCI
- Semantic verbal fluency (SVF): positive correlation (r, R2, P)
- r = 0.770, R2 = 0.593, p = 0.025
- Wechsler Memory Scale-Digit Span Test-Backward: negative correlation (r, R2, P)
- r = −0.802, R2 = 0.643, p = 0.017
Correlation of left hippocampal APTw SI with cognitive scores in T2DM-MCI
- Left head vs SVF: positive correlation (r, R2, P)
- r = 0.414, R2 = 0.172, p = 0.044
- Left tail vs Trail-Making Test-A: negative association (r, R2)
- r = −0.333, R2 = 0.111
- Left tail vs Auditory Verbal Learning Test-Huashan version-delayed recall: negative association (r, R2)
- r = −0.376, R2 = 0.141
- Both left tail associations
- P ≤ 0.021
Original publication
Early detection of type 2 diabetes mellitus‐associated cognitive dysfunction: The potential of amide proton transfer‐weighted imaging. Diabetes Obes Metab. Published 2 February 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →