Pancreatic Cystic Neoplasm Risk Among Individuals With Diabetes
Authors' conclusion
In this cohort study of 3 856 676 Korean adults, longer diabetes duration was associated with an increased risk of pancreatic cysts. The risk of pancreatic cyst occurrence was higher among younger male individuals with diabetes compared with their counterparts. Smoking cessation was associated with a lower risk of pancreatic cysts. Further studies incorporating imaging and longitudinal data are needed to clarify the clinical significance of pancreatic cysts in individuals with diabetes.
Study context
- Population
- Adults aged ≥20 years who underwent health examinations in 2009, Korea; mean age 47.1 (SD 14.0) years, 54.5% male; 330,138 (8.6%) had diabetes
- Participants
- 3,856,676 adults
- Exposure
- Diabetes status categories vs normoglycemia
- Outcome
- Pancreatic cyst occurrence (aHR by diabetes status)
- Follow-up
- Median 10.3 (IQR 10.1-10.6) years
Methodological detailsKorean National Health Insurance Service health examinations
- Korean National Health Insurance Service health examinations
Main finding
As reported in the abstract
Pancreatic cyst occurrence
Each group vs normoglycemiaAdjusted hazard ratio (95% CI)
IFG
1.06(1.03–1.08)
Shorter DM duration
1.23(1.18–1.28)
Longer DM duration
1.37(1.31–1.44)
- Developed pancreatic cysts during observation, whole cohort
- 31 877 (0.8%)
Observational data: associations, not effects.
Further findings
Pancreatic cyst occurrence associated with DM, by subgroup
- Age <60 years: aHR
- 1.34 (1.27-1.40) (95% CI)
- Age ≥60 years: aHR
- 1.21 (1.16-1.27) (95% CI)
- Males: aHR
- 1.32 (1.26-1.38) (95% CI)
- Females: aHR
- 1.20 (1.15-1.26) (95% CI)
- Current smokers: aHR
- 1.40 (1.30-1.51) (95% CI)
- Never smokers: aHR
- 1.22 (1.18-1.28) (95% CI)
- Former smokers: aHR
- 1.25 (1.16-1.35) (95% CI)
Original publication
Pancreatic Cystic Neoplasm Risk Among Individuals With Diabetes. JAMA Netw Open. Published 2 February 2026. doi:10.
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