Insulin sensitivity, disposition index and insulin clearance in cystic fibrosis: a cross-sectional study
Authors' conclusion
In individuals with PI-CF, disposition index declined with incremental impairment in glucose tolerance due to a reduction in both insulin secretion and insulin sensitivity. Moreover in CF, reduced insulin secretion was associated with higher insulin clearance.
Study context
- Population
- Individuals with cystic fibrosis and exocrine pancreatic insufficiency (pancreatic-insufficient CF (PI-CF))
- Participants
- 61 individuals
- Exposure
- Glucose tolerance categories: Normal glucose tolerance (NGT) vs early glucose intolerance (EGI) vs impaired glucose tolerance (IGT) vs CF-related diabetes (CFRD)
- Outcome
- Insulin secretion, insulin sensitivity, disposition index and insulin clearance by glucose tolerance status (oral minimal models during OGTT)
Methodological detailsextended (ten samples) OGTT, oral minimal models
- Extended (ten samples) OGTT
- Oral minimal models
Main finding
As reported in the abstract
Insulin secretion, sensitivity, disposition index and clearance by glucose tolerance
- Insulin sensitivity declined with worsening glucose tolerance
- p value for trend <0.001
- Low insulin secretion (Φ total) associated with high insulin clearance
- p<0.001
Observational data: associations, not effects.
Original publication
Insulin sensitivity, disposition index and insulin clearance in cystic fibrosis: a cross-sectional study. Diabetologia. Published 2 August 2024. doi:10.
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