The Association Between Telomere Length and Diabetes Mellitus: Accumulated Evidence From Observational Studies
Authors' conclusion
A negative correlation was observed between TL and DM. To validate this association in the interim, more extensive, superior prospective investigations and clinical trials are required.
Study context
- Population
- Participants with and without diabetes mellitus (DM) in observational studies from 14 countries; PubMed, Embase and Web of Science searched to July 11, 2023
- Participants
- 18,181 participants37 observational studies
- Comparison
- DM vs non-diabetic
- Outcome
- Telomere length (TL), pooled SMD
Methodological detailsrandom-effects model, subgroup analyses
- Random-effects model
- Subgroup analyses
Pooled result
As reported in the abstract
TL (pooled SMD)
Each group vs non-diabeticSMD (95% CI)P value
T1DMshorter TL with T1DM
−2.70(−4.47 to −0.93)
P < 0.001T2DMshorter TL with T2DM
−3.70(−4.20 to −3.20)
P < 0.001Other types of diabetesshorter TL with other types of diabetes
−0.71(−1.10 to −0.31)
P < 0.001Further pooled results
Telomere length (TL) in T2DM subgroups
- TL significantly correlated with age, sex, study design, diabetes duration, sample size, detection method, region and body mass index (BMI)
Original publication
The Association Between Telomere Length and Diabetes Mellitus: Accumulated Evidence From Observational Studies. J Clin Endocrinol Metab. Published 1 August 2024. doi:10.
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