Relationship Between 1,5-Anhydroglucitol and Renal Function Assessed by Dynamic Renal Scintigraphy in Type 2 Diabetes
Authors' conclusion
Although we observed a weak inverse correlation (r = -0.189) between mGFR and serum 1,5-AG in type 2 diabetes, 1,5-AG remains a valid marker for assessing glucose control in subjects with mild or moderate renal dysfunction.
Study context
- Population
- Participants with T2D; Measured glomerular filtration rate (mGFR) measured by 99mTc-DTPA dynamic renal scintigraphy
- Participants
- 5,337 participants
- Exposure
- mGFR categories
- mGFR ≥120n = 507
- mGFR 90-120n = 2,015
- mGFR 60-90n = 2,178
- mGFR 30-60n = 604
- mGFR <30n = 33
- Outcome
- Relationship between renal function (mGFR) and serum 1,5-AG
Main finding
As reported in the abstract
Correlation of mGFR with serum 1,5-AG
- Serum 1,5-AG overall (μg/mL)
- 3.3 (1.7-7.0)
- mGFR overall (mL/min/1.73 m²)
- 88.6 ± 24.1
- mGFR negatively correlated with 1,5-AG
- r = −0.189, P < .001
- mGFR independently and negatively related to serum 1,5-AG after adjusting for covariates incl. Hemoglobin A1c (HbA1c) (multiple linear regression)
- P < .001
Observational data: associations, not effects.
Further findings
Correlation of 1,5-AG with HbA1c, FPG, postprandial glucose and postprandial–fasting glucose difference, by mGFR subgroup
- mGFR ≥30: correlations remained significant (range)
- −0.126 to −0.743, all P < .01
- mGFR <30: link between 1,5-AG and traditional glycemic markers attenuated
Sensitivity analysis excluding anemic patients
- Similar results for 1,5-AG–HbA1c relationship across mGFR subgroups
Original publication
Relationship Between 1,5-Anhydroglucitol and Renal Function Assessed by Dynamic Renal Scintigraphy in Type 2 Diabetes. J Clin Endocrinol Metab. Published 1 August 2024. doi:10.
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