Perirenal fat and chronic kidney disease in type 2 diabetes: The mediation role of afferent arteriolar resistance
Authors' conclusion
In T2DM patients, PRF was negatively correlated with GFR, and positively correlated with RA. RA mediated the relationship between PRF and CKD.
Study context
- Population
- Patients with T2D; PRF thickness (PRFT) measured by MRI, glomerular filtration rate (GFR) and effective renal plasma flow (ERPF) by renal dynamic imaging
- Participants
- 91 patients
- Exposure
- PRFT tertile 3 vs tertile 1
- Outcome
- Relationship between PRFT and renal hemodynamics (GFR, ERPF, RVR, PGLO, RA, RE) and mediation of the PRF–chronic kidney disease (CKD) relationship
Methodological detailsmediation analysis, multiple linear regression
- Mediation analysis
- Multiple linear regression
Main finding
As reported in the abstract
Mediated proportion of perirenal fat (PRF) effect on GFR by renal vascular resistance (RVR)
29.1 %
Mediated proportion of PRF effect on GFR by RA
41.4 %
Observational data: associations, not effects.
Original publication
Perirenal fat and chronic kidney disease in type 2 diabetes: The mediation role of afferent arteriolar resistance. Diabetes Metab. Published 9 October 2024. doi:10.
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