The relationship between repeated measurements of HbA1c and risk of coronary events among the common haptoglobin phenotype groups: the Action for Health in Diabetes (Look AHEAD) study
Primary result · Incident CAD, non-Hp2-2 phenotypeResult — go to the resultAdjusted hazard ratio 0.71 95% CI 0.55–0.90Authors' conclusion
The differences in our results compared to our previous findings may be due to variations in the study populations and factors associated with weight loss, making it difficult to draw definitive conclusions. Our current findings should be considered in the context of hypothesis generation, and ideally, will encourage additional research in this field.
Study context
- Population
- Individuals with T2D (HbA1c ≤ 11% at baseline) in Look AHEAD; Hp2–2 and non-Hp2–2 phenotypes analysed separatelyHp2-2 1,587 · non-Hp2-2 2,944
- Comparison
- Achieved HbA1c <6.5%, 6.5-6.9% and ≥8.0% vs 7.0-7.9%, by haptoglobin (Hp) phenotype
- Primary endpoint
- Incident CAD
Methodological detailsCox regression with time-varying covariables, pre-specified subgroup analyses
- Cox regression with time-varying covariables
- Pre-specified subgroup analyses
Primary result
Incident CAD, non-Hp2-2 phenotype
Adjusted hazard ratio
0.71
95% CI 0.55–0.90
HbA1c < 6.5%vs HbA1c 7.0-7.9%
adjusted HR 0.71 (95% CI 0.55–0.90)
As reported in the abstract
Further findings
| Outcome | HR (CI) | |
|---|---|---|
| Incident CAD, non-Hp2-2 subgroups, HbA1c < 6.5% vs 7.0-7.9%HbA1c < 6.5%vs HbA1c 7.0-7.9%Male | 0.60 (0.44–0.83) | |
| Incident CAD, non-Hp2-2 subgroups, HbA1c < 6.5% vs 7.0-7.9%HbA1c < 6.5%vs HbA1c 7.0-7.9%No history of CVD | 0.65 (0.47–0.90) | |
| Incident CAD, non-Hp2-2 subgroups, HbA1c < 6.5% vs 7.0-7.9%HbA1c < 6.5%vs HbA1c 7.0-7.9%Aged ≥ 65 years | 0.64 (0.44–0.94) | |
| Incident CAD, non-Hp2-2 subgroups, HbA1c < 6.5% vs 7.0-7.9%HbA1c < 6.5%vs HbA1c 7.0-7.9%White | 0.68 (0.51–0.91) | |
| Incident CAD, non-Hp2-2 subgroups, HbA1c < 6.5% vs 7.0-7.9%HbA1c < 6.5%vs HbA1c 7.0-7.9%Diabetes duration > 10 years | 0.58 (0.35–0.95) | |
| Incident CAD, Hp2-2 with history of CVD, HbA1c ≥ 8.0%vs 7.0-7.9% | 1.79 (1.00–3.20) | |
| 0.20.5125Hazard ratio (log scale) |
Incident coronary artery disease (CAD), Hp2-2 phenotype, other HbA1c targets
- No associations between the other HbA1c targets and CAD risk in Hp2-2, overall or in subgroups
Original publication
The relationship between repeated measurements of HbA1c and risk of coronary events among the common haptoglobin phenotype groups: the Action for Health in Diabetes (Look AHEAD) study. Cardiovasc Diabetol. Published 9 October 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →