Intensive lifestyle intervention in type 2 diabetes and risk of incident coronary artery disease for the common haptoglobin phenotypes: the Look AHEAD study
Authors' conclusion
Hp phenotype did not modify the effect of the weight loss ILI on risk of CAD in Look AHEAD, potentially because it did not substantially impact glycemic control among participants with or without the Hp2-2 phenotype. Further research is needed to determine if these results are conclusive.
Study context
- Population
- Look AHEAD participants with T2D with haptoglobin phenotype measured; 1590 (35%) Hp2–2samples phenotyped
- Participants
- 4,542 samples
- Comparison
- Intensive lifestyle intervention (ILI) vs diabetes support and education (DSE), by haptoglobin phenotype
- Primary endpoint
- CAD events, by Hp phenotype (Hp2-2 vs non-Hp2-2)
Methodological detailspre-specified subgroups
- Pre-specified subgroups
Primary result
As reported in the abstract
CAD by Hp phenotype
ILI vs DSEHazard ratio (95% CI)
non-Hp2-2
0.95(0.78–1.17)
Hp2-2
0.89(0.68–1.19)
Further findings
HbA1c
- ILI did not lower HbA1c to < 6.5% in either phenotype; peak significant difference between arms, non-Hp2-2
- 0.5%
- Peak significant difference between arms, Hp2-2
- 0.6%
Pre-specified subgroups (race/ethnicity, sex, CVD history, diabetes medication, diabetes duration)
- No significant results in any subgroup after Bonferroni correction
Original publication
Intensive lifestyle intervention in type 2 diabetes and risk of incident coronary artery disease for the common haptoglobin phenotypes: the Look AHEAD study. Cardiovasc Diabetol. Published 24 February 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →