The Relationship Between Time-Varying Achieved HbA1c and Risk of Coronary Events Depends on Haptoglobin Phenotype Among White and Black Action to Control Cardiovascular Risk in Diabetes (ACCORD) Participants
Authors' conclusion
Achieving HbA1c >8.0% compared with 7.0-7.9% was consistently associated with incident CAD risk among White and Black ACCORD participants with the Hp2-2 phenotype, while no association was observed among participants without the Hp2-2 phenotype. We found no evidence that HbA1c concentration <7.0% prevents CAD in either Hp phenotype group.
Study context
- Population
- ACCORD participants with diabetes, Hp2–2 and non-Hp2–2 phenotypes; White (63%, 37% Hp2–2) and Black (19%, 26% Hp2–2) participantsHp2-2 3,322 · non-Hp2-2 5,949
- Comparison
- Achieved HbA1c categories vs HbA1c 7.0-7.9%, by haptoglobin (Hp) phenotype
- Primary endpoint
- CAD events
- Follow-up
- Median 4.7 years
Methodological detailstime-varying covariables, Cox proportional hazards regression, stratified by Hp phenotype and race
- Time-varying covariables
- Cox proportional hazards regression
- Stratified by Hp phenotype and race
Primary result
As reported in the abstract
CAD risk, HbA1c ≥8.0% vs 7.0-7.9%, by Hp phenotype and race
HbA1c ≥8.0% vs HbA1c 7.0-7.9%Adjusted hazard ratio (95% CI)
White, Hp2-2
1.43(1.03–1.98)
Black, Hp2-2
2.86(1.09–7.51)
All Hp2-2 combined
1.30(0.99–1.70)
Original publication
The Relationship Between Time-Varying Achieved HbA1c and Risk of Coronary Events Depends on Haptoglobin Phenotype Among White and Black ACCORD Participants. Diabetes Care. Published 28 August 2023. doi:10.
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