Association of prior outpatient diabetes screening with cardiovascular events and mortality among people with incident diabetes: a population-based cohort study
Authors' conclusion
Previously screened individuals with diabetes had lower risks of cardiovascular events and mortality versus previously unscreened individuals. Better risk assessment tools are needed to support wider and more appropriate uptake of diabetes screening, especially among young adults.
Study context
- Population
- Adults aged ≥ 20 years with incident diabetes diagnosed 2014–2016, Ontario, Canada70.2% previously screened
- Participants
- 178,753 adults
- Exposure
- Prior outpatient diabetes screening vs no prior screening
- Outcome
- Co-primary: (1) composite of all-cause mortality and hospitalization for MI, stroke, coronary revascularization; (2) all-cause mortality
- Follow-up
- Followed up until 2018
Methodological detailsadministrative databases, cause-specific hazard modelling accounting for competing risk of death
- Administrative databases
- Cause-specific hazard modelling accounting for competing risk of death
Main finding
As reported in the abstract
Prior screening vs No prior screeningEstimate (CI)
34% lower risk
aHR (composite) 0.66(0.63–0.69)
32% lower risk
aHR (mortality) 0.68(0.64–0.72)
- Standardized composite event rate, prior screening vs no prior screening (per 1000 patient-years)
- 12.8 vs 18.1
- Standardized mortality rate, prior screening vs no prior screening (per 1000 patient-years)
- 8.2 vs 11.1
Observational data: associations, not effects.
Further findings
| Outcome | Estimate | |
|---|---|---|
| Prediabetes-range vs normoglycemic-range screening result, among screenedPrediabetes rangevs Normoglycemic range | aHR (composite) 0.82 (CI 0.77–0.88) | |
| Prediabetes-range vs normoglycemic-range screening result, among screenedPrediabetes rangevs Normoglycemic range | aHR (mortality) 0.71 (CI 0.66–0.78) | |
| 0.512Ratio (log scale) |
Baseline characteristics
- Age, prior screening vs no prior screening (years)
- 58.3 vs 53.4
- Women, prior screening vs no prior screening
- 49.6% vs 40.0%
Original publication
Association of prior outpatient diabetes screening with cardiovascular events and mortality among people with incident diabetes: a population-based cohort study. Cardiovasc Diabetol. Published 28 August 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →