Long-Term Glycemic Variability Predicts Adverse Outcomes in Diabetic Heart Failure With Preserved Ejection Fraction
Main finding · Hospitalization for HF (HHF)Result — go to the resultHazard ratio 1.32 95% CI 1.04–1.69Authors' conclusion
Our study highlights a significant association between increased GV and a higher incidence of HHF as well as an elevated overall mortality rate in individuals with diabetes and HFpEF.
Study context
- Population
- Patients with DM and heart failure with preserved ejection fraction (HFpEF) with FGCV measured, tertiary medical center in Taiwan, 2014–2019from 74,835 with DM
- Participants
- 753 patients
- Exposure
- Highest vs lowest tertile of fasting glucose coefficient of variability
- Outcome
- Hospitalization for HF (hospitalization for heart failure (HHF))
- Follow-up
- Median 38.1 months
Methodological detailssingle tertiary medical center, electronic medical records
- Single tertiary medical center
- Electronic medical records
Main finding
As reported in the abstract
Hazard ratio
1.32
95% CI 1.04–1.69
P = 0.025
Third FGCV tertilevs First FGCV tertile
HR 1.32 (95% CI 1.04–1.69); P = 0.025
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Overall mortality · median follow-up 38.1 months | 1.65 (1.16–2.35) | P = 0.005 | |
| 0.512Hazard ratio (log scale) |
- Overall mortality: Kaplan-Meier: log-rank P <.001
Atrial fibrillation (AF) and CV mortality
- Highest FGCV tertile not associated with increased AF or CV mortality
Original publication
Long-Term Glycemic Variability Predicts Adverse Outcomes in Diabetic Heart Failure With Preserved Ejection Fraction. J Clin Endocrinol Metab. Published 9 October 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →