Analysis of the global burden of CKD-T2DM in young and middle-aged adults in 204 countries and territories from 2000 to 2019: A systematic study of the global burden of disease in 2019
Authors' conclusion
ver the past 20 years, the burden of CKD-T2DM among young and middle-aged individuals globally has continued to increase, with disparities existing among different countries, regions, and age groups, but overall showing an upward trend. The reasons for this trend are multifaceted, including global lifestyle changes such as dietary shifts, sedentary lifestyles, obesity, as well as population aging and inadequate preventive measures in certain regions. Addressing these challenges necessitates optimizing screening methods, adjusting lifestyles, enhancing management strategies, improving medical care and awareness levels, particularly intensifying awareness and screening efforts among males, reinforcing prevention and control measures for the 45-49 age group, enhancing infrastructure and healthcare resources in developing countries, fostering international collaboration, and implementing context-specific measures.
Study context
- Population
- Young and middle-aged adults with CKD due to T2D (CKD-T2DM), global, regional and national levels, Global Burden of Disease (GBD) database
- Outcome
- Burden of CKD-T2DM (incidence, mortality, DALYs)
- Follow-up
- 2000 to 2019
Methodological detailsglobal, regional and national estimates, 2000–2019, estimated annual percentage change (EAPC) trend analysis, age-stratified
- Global, regional and national estimates
- 2000–2019
- EAPC trend analysis
- Age-stratified
Main finding
As reported in the abstract
- Disease burden of CKD-T2DM among young and middle-aged individuals globally showed a sustained increase from 2000 to 2019
- Incidence, mortality and DALYs rates showed an overall upward trend, higher in males than females
- Highest number of new cases: India, China and Mexico
- Highest Age-standardized Incidence Rate (ASIR): Nicaragua, Mexico and United Arab Emirates; lowest: Uganda, Ethiopia and Burundi
- Burden varied among age groups but generally rose, particularly in the 45-49 age bracket
Further findings
Risk factors for mortality and DALYs
- High systolic blood pressure and high BMI were the primary contributing factors, with variations across regions and development levels
Original publication
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