Effects of garlic supplementation on glycemic indices in adults: a GRADE-assessed systematic review and dose–response meta-analysis of randomized controlled trials
Authors' conclusion
Garlic supplementation may lead to modest improvements in glycemic control, particularly in FBG and HbA1c
Study context
- Population
- Adults in randomized controlled trials (RCTs) of garlic supplementation; PubMed, Scopus and Web of Science searched up to January 2026
- Participants
- 1,619 adults27 RCTs
- Comparison
- Garlic supplementation vs control
- Outcome
- Glycemic indices
Methodological detailsGRADE-assessed, nonlinear dose-response analysis, subgroup, sensitivity and meta-regression analyses
- GRADE-assessed
- Nonlinear dose-response analysis
- Subgroup, sensitivity and meta-regression analyses
Pooled result
As reported in the abstract
WMD (FBG), mg/dL (95% CI)
Garlic
−2.76(−5.11 to −0.41)
WMD (HbA1c), % (95% CI)
Garlic
−0.53(−0.86 to −0.20)
WMD (insulin), μIU/mL (95% CI)
Garlic
−1.18(−2.91 to 0.55)
WMD (HOMA-IR) (95% CI)
Garlic
−0.30(−0.72 to 0.12)
Further pooled results
Nonlinear dose-response
- Greater reductions in fasting blood glucose (FBG) and insulin at lower doses (≤0.5 g/day)
Original publication
Effects of garlic supplementation on glycemic indices in adults: a GRADE-assessed systematic review and dose–response meta-analysis of randomized controlled trials. Diabetes Res Clin Pract. Published 3 July 2026. doi:10.
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