Orthostatic Hypotension Promotes the Progression From Mild Cognitive Impairment to Dementia in Type 2 Diabetes Mellitus
Authors' conclusion
In T2DM with MCI patients, AD biomarkers and complement proteins mediate the effects of OH on cognitive impairment and OH may be a risk factor of progression from MCI to dementia in T2DM.
Study context
- Population
- Patients with T2D and mild cognitive impairment (MCI)
- Exposure
- Orthostatic hypotension (OH) vs no OH in T2D with MCI
- Outcome
- Progression from MCI to dementia
Methodological detailsmediation analysis, Cox proportional-hazards regression, Complement proteins of astrocyte-derived exosomes and Alzheimer's disease (AD) biomarkers of neuronal cell-derived exosomes quantified by ELISA; cognitive assessments at enrollment and follow-up
- Mediation analysis
- Cox proportional-hazards regression
- Complement proteins of astrocyte-derived exosomes and AD biomarkers of neuronal cell-derived exosomes quantified by ELISA; cognitive assessments at enrollment and follow-up
Main finding
As reported in the abstract
- OH group had a higher risk of developing dementia vs T2D without OH (Cox proportional-hazards regression)
Observational data: associations, not effects.
Further findings
Mediation of OH effect on cognition · baseline
- Influence of OH on cognition in T2D partly mediated by baseline AD biomarkers and complement proteins
Original publication
Orthostatic Hypotension Promotes the Progression From Mild Cognitive Impairment to Dementia in Type 2 Diabetes Mellitus. J Clin Endocrinol Metab. Published 2 January 2024. doi:10.
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