Patterns of metformin use and glycated haemoglobin trends among patients with newly diagnosed type 2 diabetes in Alberta, Canada
Authors' conclusion
Identifying characteristics associated with discontinuation of metformin and individuals' medication usage patterns provide an opportunity for targeted interventions to support patients' glycaemic management.
Study context
- Population
- Individuals with newly diagnosed uncomplicated T2D initiating metformin, Alberta, Canada, 2012–2017
- Exposure
- Patterns of metformin use
- Outcome
- Individual and clinical factors associated with metformin discontinuation
Methodological detailslinked administrative datasets
- Linked administrative datasets
Main finding
As reported in the abstract
Factors associated with metformin discontinuation
- Younger age, lower baseline HbA1c and fewer comorbidities associated with discontinuation
- Sex, income and location (urban/rural) not significantly associated with discontinuation
Observational data: associations, not effects.
Further findings
HbA1c by metformin usage pattern · 12 months from treatment initiation
- Lowest HbA1c with continued metformin with higher adherence and with entire discontinuation
- Higher HbA1c with changed therapy or added therapies
Original publication
Patterns of metformin use and glycated haemoglobin trends among patients with newly diagnosed type 2 diabetes in Alberta, Canada. Diabetes Obes Metab. Published 2 January 2024. doi:10.
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