Beyond glycated haemoglobin: Modelling contemporary management of type 2 diabetes with the updated Cardiff model
Authors' conclusion
Predictions based on a glucose-centric approach to therapy are likely to deviate from real-world observations. A holistic approach is more able to capture the nuances of contemporary clinical practice. T2D modelling must evolve to remain robust and relevant.
Study context
- Population
- Modelled newly diagnosed T2D population
- Comparison
- Holistic vs conventional approach to therapy selection/escalation
- Outcome
- Predicted outcomes and costs
Methodological detailsupdated Cardiff T2D model, risk factor progression equations based on UKPDS90, Cardio-kidney-metabolic benefits of SGLT2i and GLP-1 RA captured via novel risk equations derived from outcomes trial data
- Updated Cardiff T2D model
- Risk factor progression equations based on UKPDS90
- Cardio-kidney-metabolic benefits of SGLT2i and GLP-1 RA captured via novel risk equations derived from outcomes trial data
Main finding
As reported in the abstract
- Holistic approach enables early introduction of SGLT2i and GLP-1 RA in modelled pathways, aligned to guidelines and primarily due to elevated cardiovascular (CV) risk
- Vs conventional approach (HbA1c only), fewer clinical events and additional health benefits with holistic approach
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Beyond glycated haemoglobin: Modelling contemporary management of type 2 diabetes with the updated Cardiff model. Diabetes Obes Metab. Published 19 January 2025. doi:10.
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