Long‐term effects of a multidomain intervention on cognitive function and metabolic control in older adults with type 2 diabetes and mild cognitive impairment: A 42‐month follow‐up of the J‐ MIND ‐Diabetes study
Authors' conclusion
Multidomain interventions appear to provide sustained benefits for executive function and metabolic control in older adults with type 2 diabetes and MCI. Further studies should be performed to validate these findings.
Study context
- Population
- Outpatients aged 70–85 years with T2D and mild cognitive impairment (MCI)analysed
- Participants
- 42 outpatients
- Comparison
- 18-month multidomain intervention vs standard diabetes care
- Interventionn = 22
- Controln = 20reference
- Primary endpoint
- Change in the composite cognitive Z-score
- Follow-up
- 42 months
Methodological details42-month follow-up, Neuropsychological assessments at 6, 18, 30, and 42 months
- 42-month follow-up
- Neuropsychological assessments at 6, 18, 30, and 42 months
Primary result
Change in composite cognitive Z-score
Between-group difference
0.19
95% CI −0.14 to 0.52
Between Intervention and Control
between-group difference 0.19 (95% CI −0.14 to 0.52)
As reported in the abstract
Further findings
| Outcome | Between-group difference (95% CI) | |
|---|---|---|
| Trail making test part A · 42 monthsSignificant benefit with intervention · MMRM | −18.0 (−28.7 to −7.19) | |
| Trail making test part B · 42 monthsSignificant benefit with intervention · MMRM | −26.2 (−50.5 to −1.91) | |
| −100−50050Difference (linear scale) |
Change in %TIR 70-180 mg/dL (CGM)
- Significant between-group difference in change in %TIR 70-180 mg/dL
- 16.2 (95% CI: 0.96-31.5)
Original publication
Long‐term effects of a multidomain intervention on cognitive function and metabolic control in older adults with type 2 diabetes and mild cognitive impairment: A 42‐month follow‐up of the J‐ MIND ‐Diabetes study. Diabetes Obes Metab. Published 8 January 2026. doi:10.
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