Effects of Tai Chi Chuan on Cognitive Function in Adults 60 Years or Older With Type 2 Diabetes and Mild Cognitive Impairment in China: A Randomized Clinical Trial
Primary result · MoCA scoreResult — go to the resultBetween-group mean difference 0.84 95% CI 0.02–1.66Authors' conclusion
In this randomized clinical trial including older adults with T2D and MCI, tai chi chuan was more effective than fitness walking in improving global cognitive function. The findings support a long-term benefit, suggesting the potential clinical use of tai chi chuan as an exercise intervention to improve cognitive function for older adults with T2D and MCI.
Study context
- Population
- Adults aged ≥60 years with T2D and mild cognitive impairment (MCI), 4 sites in China; all groups received diabetes self-management educationITT analysis
- Participants
- 328 adults
- Comparison
- Tai chi chuan vs fitness walking vs control
- Tai chi chuann = 107
- Fitness walkingn = 110
- Controln = 111reference
- Primary endpoint
- Global cognitive function by Montreal Cognitive Assessment (MoCA)
- Follow-up
- 36 weeks
Methodological detailsmulticentre (4 sites), 3-arm, randomized 1:1:1, Conducted June 1, 2020 – February 28, 2022; follow-up 36 weeks
- Multicentre (4 sites)
- 3-arm
- Randomized 1:1:1
- Conducted June 1, 2020 – February 28, 2022; follow-up 36 weeks
Primary result
MoCA score
Between-group mean difference
0.84
95% CI 0.02–1.66
P = 0.046
By group
Tai chi chuan
24.67
mean · SD 2.72
Fitness walking
23.84
mean · SD 3.17
Tai chi chuanvs Fitness walking
between-group mean difference 0.84 (95% CI 0.02–1.66); P = 0.046
As reported in the abstract
Secondary outcomes
Montreal Cognitive Assessment (MoCA), per-protocol and subgroup analyses · 36 weeks
- Per-protocol and subgroup analyses showed similar results
Safety
Events
| Outcome | Tai chi chuan | Fitness walking | Control | P value |
|---|---|---|---|---|
| Nonserious adverse events, unrelated to studyBetween Tai chi chuan and Fitness walking | 8 | 13 | 16 | P = 0.26 |
- Nonserious adverse events, unrelated to study — Total nonserious AEs
- 37
- Nonserious adverse events, unrelated to study: among the 3 groups (incl. control); no significant difference
Original publication
Effects of Tai Chi Chuan on Cognitive Function in Adults 60 Years or Older With Type 2 Diabetes and Mild Cognitive Impairment in China: A Randomized Clinical Trial. JAMA Netw Open. Published 3 April 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →