Differential effects of a multidomain intervention on cognitive decline in older adults with type 2 diabetes according to white matter hyperintensity status: A secondary analysis of the J‐ MIND ‐Diabetes
Authors' conclusion
Older adults with type 2 diabetes and WMH may benefit from multidomain interventions. Further studies should be performed to validate this finding.
Study context
- Population
- Adults aged 70–85 years with T2D and mild cognitive impairment; WMH assessed by Fazekas scale90 analysed
- Participants
- 154 adults
- Comparison
- Multidomain intervention vs control, by baseline WMH status
- Primary endpoint
- Change in average Z-scores from all neuropsychological tests combined
- Follow-up
- Baseline to 18 months
Primary result
As reported in the abstract
Change in composite Z-score, by baseline WMH · 18 months
Z-score difference
+0.335
95% CI +0.045 to +0.624
with WMH
Z-score difference
−0.121
95% CI −0.353 to +0.110
without WMH
- Intervention-WMH interaction
- P = 0.017
- Participants with moderate to severe WMH
- 34
Original publication
Differential effects of a multidomain intervention on cognitive decline in older adults with type 2 diabetes according to white matter hyperintensity status: A secondary analysis of the J‐ MIND ‐Diabetes. Diabetes Obes Metab. Published 14 July 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →