Sex Hormones and Diabetes in 45- to 74-year-old Men and Postmenopausal Women: The Hispanic Community Health Study
Authors' conclusion
Stronger associations of testosterone and SHBG with transition from prediabetes to diabetes than from normoglycemic to prediabetes suggest they are operative at later stages of diabetes development.
Study context
- Population
- Men and postmenopausal women aged 45 to 74 years without diabetes at baseline, Hispanic Community Health Study/Study of Latinos; baseline hormones: estradiol, luteinizing hormone (LH), follicle stimulating hormone (FSH), sex hormone-binding globulin (SHBG), dehydroepiandrosterone sulfate (DHEAS) and, in men, testosterone and bioavailable testosterone
- Participants
- 1,015 vs 693
- Exposure
- Associations of baseline endogenous sex hormones with incident diabetes, prediabetes and diabetes traits
- Menn = 1,015
- Postmenopausal womenn = 693
- Outcome
- Incident diabetes, prediabetes and diabetes traits
- Follow-up
- 6 years
Methodological detailsmultivariable Poisson and linear regression
- Multivariable Poisson and linear regression
Main finding
As reported in the abstract
Conversion from prediabetes to diabetes
Incidence rate ratio (95% CI)P value
Men: testosterone (per 1 SD increase)
0.821(0.676–0.997)
P = 0.046Women: SHBG
0.62(0.44–0.86)
P = 0.005Per 1 SD increase, as printed
Observational data: associations, not effects.
Further findings
Diabetes traits in men
- Estradiol positively associated with increase in fasting insulin and HOMA-IR
Diabetes traits in women
- SHBG inversely associated with change in HbA1c and postload glucose
- Relationships with other hormones varied across glycemic measures
Original publication
Sex Hormones and Diabetes in 45- to 74-year-old Men and Postmenopausal Women: The Hispanic Community Health Study. J Clin Endocrinol Metab. Published 12 January 2023. doi:10.
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