Sex Hormones and Cardiovascular Risk in Type 2 Diabetes: Cohort Study of the Look AHEAD Trial
Authors' conclusion
In men with T2D, but not women with T2D, sex hormones were associated with CV events.
Study context
- Population
- Adults with T2D in the Look AHEAD trial (lifestyle intervention)488 cardiovascular (CV) events
- Participants
- 2,260 adults
- Exposure
- Sex-specific tertiles of baseline sex hormones and sex hormone binding globulin (SHBG) and their 1-year changes
- Outcome
- CV events
Methodological detailscohort of the Look AHEAD trial, sex-specific tertiles
- Cohort of the Look AHEAD trial
- Sex-specific tertiles
Main finding
As reported in the abstract
Men: higher baseline total testosterone, HR (95% CI 0.56-0.97); lower CV risk
0.74
Men with ≥7% weight loss: SHBG increases, HR (95% CI 0.26-0.85); inversely associated with CV risk
0.47
Men with <7% weight loss: second vs first estradiol tertile, HR
1.64
95% CI 1.13–2.38
Men with <7% weight loss: third vs first estradiol tertile, HR
1.88
95% CI 1.29–2.73
Observational data: associations, not effects.
Original publication
Sex Hormones and Cardiovascular Risk in Type 2 Diabetes: Cohort Study of the Look AHEAD Trial. Diabetes Care. Published 26 January 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →