Epigenetic age acceleration and metabolic syndrome among Hispanic/Latino adults: Hispanic Community Health Study/Study of Latinos (HCHS/SOL)
Authors' conclusion
The study suggests EAA is a potential indicator of both prevalent and incident MetS among Hispanic/Latino adults.
Study context
- Population
- Hispanic/Latino adults in the Hispanic Community Health Study/Study of Latinos; baseline mean age 44.8 years, 61.5% female, metabolic syndrome (MetS) prevalence 35.4%random sample
- Participants
- 962 adults
- Exposure
- Epigenetic age acceleration and MetS
- Outcome
- Prevalent MetS (cross-sectional) and incident MetS
Methodological detailscross-sectional and longitudinal analyses, random sample, MetS defined by NCEP ATP III criteria (≥3 of 5 conditions), DNA methylation measured from whole blood at two time points six years apart (Illumina EPIC BeadChip)
- Cross-sectional and longitudinal analyses
- Random sample
- MetS defined by NCEP ATP III criteria (≥3 of 5 conditions)
- DNA methylation measured from whole blood at two time points six years apart (Illumina EPIC BeadChip)
Main finding
As reported in the abstract
- Higher PhenoAA and prevalent MetS, PR
- 1.03 (1.01, 1.05) (95% CI)
- Higher GrimAA and prevalent MetS, PR
- 1.05 (1.01, 1.09) (95% CI)
- Higher DunedinPACE and prevalent MetS, PR
- 1.03 (1.02, 1.04) (95% CI)
- Higher baseline DunedinPACE and incident MetS over ≈6 years, RR
- 1.04 (1.02, 1.05) (95% CI)
- Faster DunedinPACE rates (vs average) and incident MetS, RR
- 1.44 (1.07, 1.94) (95% CI)
- Slower DunedinPACE rates (vs average) and incident MetS, RR
- 0.44 (0.23, 0.87) (95% CI)
Observational data: associations, not effects.
Original publication
Epigenetic age acceleration and metabolic syndrome among Hispanic/Latino adults: Hispanic Community Health Study/Study of Latinos (HCHS/SOL). Int J Obes (Lond). Published 12 August 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →