Gestational diabetes & diabetes in pregnancy
Real‐world evaluation of the National Health Service (NHS) testing criteria for glucokinase hyperglycaemia in pregnancy
Authors' conclusion
Current criteria may not effectively identify a high-risk cohort of individuals to test, given the prevalence of GCK-MODY in those tested, leading to over-testing. HbA1c may prove a useful additional screening parameter. Further studies are needed to improve the criteria's utility across different ethnicities.
Study context
- Population
- Women with gestational diabetes that met criteria for Glucokinase-Maturity Onset Diabetes of the Young (GCK-MODY) genetic testing, multi-ethnic population
- Exposure
- Patient characteristics in those positive and negative for GCK-MODY
- Outcome
- Cases of GCK-MODY found when testing using NHS criteria
Methodological detailsmulti-ethnic cohort
- Multi-ethnic cohort
Main finding
As reported in the abstract
Found using NHS criteria
0.14%
Expected
0.9%
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| HbA1cHigher with GCK-MODY positive | P < 0.001 |
| 2-h glucose incrementNo difference | P = 0.829 |
Original publication
Real‐world evaluation of the NHS testing criteria for glucokinase hyperglycaemia in pregnancy. Diabet Med. Published 13 November 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →