Development of a Calculator for HNF1A- and HNF4A-MODY in Asian Indians
Authors' conclusion
We developed an ethnicity-specific calculator to help identify individuals with possible HNF1A-MODY or HNF4A-MODY in Asian Indians. This user-friendly, web-based tool would be helpful to select candidates for genetic testing in this population.
Study context
- Population
- Asian Indians with young-onset diabetes aged <30 years from electronic records; genetically confirmed HNF1A- and HNF4A-MODY with 1000 each of T1D and T2Drecords extracted · HNF4A-MODY 55
- Participants
- 29,191 participants
- Comparison
- Clinical prediction models distinguishing HNF1A/HNF4A-MODY from T1D and from T2D
- Outcome
- Discriminative performance (ROC-AUC) of models for HNF1A-/HNF4A-MODY
Methodological detailslogistic regression, internal and external validation, five-fold cross-validation, Online calculator at https://mdrf-t1d-calculator.shinyapps.io/MODY/
- Logistic regression
- Internal and external validation
- Five-fold cross-validation
- Online calculator at https://mdrf-t1d-calculator.shinyapps.io/MODY/
Performance
As reported in the abstract
ROC-AUC
| Test or model | Value | AUC |
|---|---|---|
| Models 1–4 | 0.884 to 0.957 | 0.884 to 0.957 |
| Models 5–8 | 0.914 to 0.936 | 0.914 to 0.936 |
Value
Models 1–40.884 to 0.957
Models 5–80.914 to 0.936
AUC
Models 1–40.884 to 0.957
Models 5–80.914 to 0.936
Further findings
- All models showed excellent performance in internal validation, with high five-fold cross-validation c-statistics
Original publication
Development of a Calculator for HNF1A- and HNF4A-MODY in Asian Indians. J Diabetes Sci Technol. Published 23 March 2026. doi:10.
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