Cardiovascular disease risk prediction and profiling among Asian Indians with young‐onset type 1 and type 2 diabetes
Authors' conclusion
Both QRISK and FRS were good predictors of CVD in this population. Individuals with young-onset diabetes have a high propensity to develop cardiovascular disease within 10 years, with T2D having a higher risk than T1D. Regular risk monitoring, lifestyle modifications and medical interventions are essential among individuals with young-onset T2D and T1D.
Study context
- Population
- Asian Indians with T1D or T2D, age of onset 10 to 30 years, from Diabetes Electronic Medical Records; preexisting cardiovascular disease (CVD) excludedpreexisting CVD excluded 175
- Participants
- 18,837 participants
- Exposure
- QRISK3 vs Framingham Risk Score (FRS) for 10-year CVD risk prediction; T2D vs T1D
- Outcome
- Proportion with high CVD risk (QRISK3 or FRS score ≥10.0%) and predictive ability of QRISK3 and FRS
- Follow-up
- 10-year risk
Methodological detailsQRISK3 calculated for 5371 and FRS for 7444 individuals
- QRISK3 calculated for 5371 and FRS for 7444 individuals
Main finding
As reported in the abstract
High CVD risk score (≥10.0%)
High QRISK3
High FRS
- T2D vs T1D: P < 0.001 — higher risk with T2D by both scores
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Predictive ability for 10-year CVD risk (ROC-AUC)QRISK3 vs FRS · QRISK3 0.788; FRS 0.746 | P = 0.241 |
- Predictive ability for 10-year CVD risk (receiver operating characteristic-area under the curve (ROC-AUC)) — QRISK3 AUC
- 0.788
- Predictive ability for 10-year CVD risk (ROC-AUC) — FRS AUC
- 0.746
High-risk scores by age and sex
- Frequency of high-risk scores increased with age and was higher among men
Original publication
Cardiovascular disease risk prediction and profiling among Asian Indians with young‐onset type 1 and type 2 diabetes. Diabet Med. Published 28 February 2025. doi:10.
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