Comprehensive analysis of the association between triglyceride-glucose index and coronary artery disease severity across different glucose metabolism states: a large-scale cross-sectional study from an Asian cohort
Authors' conclusion
The TyG index positively associated with CAD severity across all glucose metabolism states, except for individuals receiving insulin treatment. Moreover, it might serve as a supplementary noninvasive predictor of CAD severity in addition to established factors, especially in NGR patients.
Study context
- Population
- Asian cohort participants assessed for coronary artery disease (CAD) severity, categorized by glucose metabolism state; Triglyceride-glucose (TyG) index = Ln [TG (mg/dL) × FPG (mg/dL) / 2]
- Participants
- 10,433 participants
- Exposure
- TyG index and CAD severity across glucose metabolism states
- Outcome
- Multi-vessel CAD (CAD severity)
Methodological detailsparticipants from a prospective cohort
- Participants from a prospective cohort
Main finding
As reported in the abstract
Multi-vessel CAD, per 1-unit TyG increment, multivariable logistic regression
| Group | OR |
|---|---|
| Normal glucose regulation (NGR) | 1.67 (95% CI 1.3-2.14) |
Normal glucose regulation (NGR)
OR1.67 (95% CI 1.3-2.14)
- Entire population: OR per 1-unit increment
- 1.34 (95% CI 1.22-1.47)
Observational data: associations, not effects.
Further findings
Dose-response (restricted cubic spline (RCS))
- Distinct dose-response relationships across glucose metabolism subgroups
Predictive accuracy
- Adding TyG index to established model slightly improved predictive accuracy, particularly in NGR
Mediation by HbA1c
- Varying mediating effects of HbA1c among glucose metabolism subgroups
Sensitivity analysis
- Robustness confirmed in new-onset CAD population and in individuals not using antilipidemic medications
Original publication
Comprehensive analysis of the association between triglyceride-glucose index and coronary artery disease severity across different glucose metabolism states: a large-scale cross-sectional study from an Asian cohort. Cardiovasc Diabetol. Published 13 July 2024. doi:10.
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