Associations of cumulative exposure and longitudinal change patterns of the triglyceride glucose–Chinese visceral adiposity index with incident cardiovascular disease in middle-aged and older adults: evidence from China Health and Retirement Longitudinal Study (CHARLS)
Authors' conclusion
Higher cumulative TyG-CVAI burden and unfavorable longitudinal change patterns were associated with an increased risk of incident CVD among middle-aged and older Chinese adults. These findings suggest that repeated TyG-CVAI assessment may help identify individuals with sustained or worsening metabolic-visceral burden and support longitudinal cardiovascular risk stratification.
Study context
- Population
- Middle-aged and older Chinese adults free of cardiovascular disease (CVD) 2011–2015 with complete triglyceride glucose-Chinese visceral adiposity index (TyG-CVAI) data in 2011 and 2015 (CHARLS)
- Participants
- 4,338 participants
- Exposure
- TyG-CVAI change patterns and cumulative TyG-CVAI exposure
- Outcome
- Incident CVD (new-onset heart disease or stroke)
- Follow-up
- Mean 5 years
Methodological detailsCHARLS, repeated measurements 2011–2015
- CHARLS
- Repeated measurements 2011–2015
Main finding
As reported in the abstract
Incident CVD by TyG-CVAI change pattern
Each group vs low-lowHazard ratio (95% CI)
Low-high
1.50(1.21–1.88)
High-low
1.64(1.20–2.25)
High-high
1.77(1.49–2.09)
- Incident CVD events
- 845
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Incident CVD by cumulative TyG-CVAI quartileHighest quartilevs Lowest quartile | 1.91 (1.56–2.33) | P for trend < 0.001 | |
| 0.512Hazard ratio (log scale) |
Incident CVD per 1-SD increase in cumulative TyG-CVAI
- HR per 1-SD increase (fully adjusted), 95% CI 1.06-1.14
- 1.10
Dose-response (restricted cubic spline (RCS))
- Significant nonlinear association between cumulative TyG-CVAI and incident CVD
Original publication
Associations of cumulative exposure and longitudinal change patterns of the triglyceride glucose–Chinese visceral adiposity index with incident cardiovascular disease in middle-aged and older adults: evidence from CHARLS. Cardiovasc Diabetol. Published 26 June 2026. doi:10.
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