Accessing the relationship between six surrogate insulin resistance indexes and the incidence of rapid kidney function decline and the progression to chronic kidney disease among middle-aged and older adults in China: Results from the China health and retirement longitudinal study
Authors' conclusion
In this study we proved six insulin resistance indexes were predictively associated with RKFD in Chinese with normal renal function over age 45. TyGWC is the best insulin resistance index for predicting RKFD. CVAI is the best index for predicting further progression to CKD.
Study context
- Population
- Chinese adults ≥45 years with normal kidney function (eGFRcr-cys ≥60 ml/min per 1.73 m²) at baseline (2011)
- Participants
- 3,899 adults
- Exposure
- Six surrogate insulin resistance indexes for rapid kidney function decline (RKFD) and progression to chronic kidney disease (CKD)
- Outcome
- RKFD: annualized decline in eGFRcr-cys of 5 ml/min per 1.73 m² or more
- Follow-up
- 3.99 years
Methodological detailsChina Health and Retirement Longitudinal Study, logistic analysis, ROC curves, subgroup analysis by diabetes or hypertension status
- China Health and Retirement Longitudinal Study
- Logistic analysis
- ROC curves
- Subgroup analysis by diabetes or hypertension status
Main finding
As reported in the abstract
RKFD · 3.99 years
- Participants with RKFD
- 191
- Per SD increase of all six insulin resistance indexes significantly associated with RKFD incidence
- all P < 0.01
Observational data: associations, not effects.
Secondary outcomes
Progression to CKD (RKFD plus eGFRcr-cys <60 ml/min per 1.73 m² at exit visit)
- Participants progressed to CKD
- 66
- Per SD increase of Chinese Visceral Adiposity Index (CVAI), Lipid Accumulation Product (LAP), triglyceride-glucose × Body Mass Index (TyGBMI) and triglyceride-glucose × waist circumference (TyGWC) significantly associated with progression to CKD
- all P < 0.01
- CVAI had better predictive role than other indexes
Subgroups by diabetes or hypertension status
- Association with progression to CKD more significant in subjects with hypertension or without diabetes
- No significant differences observed for RKFD
Original publication
Accessing the relationship between six surrogate insulin resistance indexes and the incidence of rapid kidney function decline and the progression to chronic kidney disease among middle-aged and older adults in China: Results from the China health and retirement longitudinal study. Diabetes Res Clin Pract. Published 10 May 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →