Percent Time Below Range Is Strongly Associated with Clinically Important Level 2 Hypoglycemia Events in Individuals with Type 1 Diabetes
Authors' conclusion
L2 event frequency and %T < 54 are strongly correlated, but the relationship differs by L2 event duration. Therefore, both frequency and duration of L2 events should be reported together. Time-below-range metrics incorporate both aspects and are core CGM endpoints that summarize overall amount of hypoglycemia exposure.
Study context
- Population
- Individuals with T1D from eight clinical trials over 3–6 months; mean age 37 ± 21 years, 72% adults; 43% using automated insulin delivery (AID), 43% continuous glucose monitoring (CGM) users not using AID, 14% self-monitoring blood glucose (SMBG) users not using CGM
- Participants
- 1,532 individuals
- Outcome
- Relationship between CGM-measured % time <54 mg/dL (%T < 54) and level 2 hypoglycemic events (≥15 min <54 mg/dL)
Pooled result
As reported in the abstract
Correlation between %T < 54 and L2 event rate (r)
0.97
Predicted L2 events/week at 1% T < 54, short L2 events (average <30 min)
2.4
Predicted L2 events/week at 1% T < 54, medium L2 events (average 30-60 min)
1.9
Predicted L2 events/week at 1% T < 54, long L2 events (average >60 min)
1.2
Further pooled results
L2 events per week by meeting hypoglycemic targets
- Meeting targets (<1% T < 54): average L2 events/week, irrespective of technology use
- 0.6
- Not meeting targets (≥1% T < 54): average L2 events/week; differed by technology use and observed %T < 54
- 2.9
Original publication
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