Increased Derived Time in Range Is Associated with Reduced Risk of Major Adverse Cardiovascular Events, Severe Hypoglycemia, and Microvascular Events in Type 2 Diabetes: A Post Hoc Analysis of DEVOTE
Study context
- Population
- People with T2D in the DEVOTE trial
- Comparison
- Association of derived TIR (dTIR) at 12 months with time to cardiovascular, severe hypoglycaemic and microvascular events
- Primary endpoint
- Association between dTIR (from 8-point glucose profiles) and time to MACE, severe hypoglycaemic episode or microvascular event
- Follow-up
- 12 months
Methodological detailspost hoc analysis
- Post hoc analysis
Primary result
As reported in the abstract
dTIR and time to events
- dTIR significantly negatively associated with time to first MACE
- P = 0.0087
- dTIR significantly negatively associated with time to severe hypoglycaemic episode
- P < 0.0001
- dTIR significantly negatively associated with time to microvascular event
- P = 0.024
Further findings
12-month hemoglobin A1c (HbA1c) and these outcomes
- Nonsignificant trend toward association; no longer seen after addition of dTIR to the model
Original publication
Increased Derived Time in Range Is Associated with Reduced Risk of Major Adverse Cardiovascular Events, Severe Hypoglycemia, and Microvascular Events in Type 2 Diabetes: A Post Hoc Analysis of DEVOTE. Diabetes Technol Ther. Published 8 May 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →