Multiple triglyceride-derived metabolic indices and incident cardiovascular outcomes in patients with type 2 diabetes and coronary heart disease
Authors' conclusion
Our study, for the first time, may provide valuable information that multiple TG-derived metabolic indices play a crucial role in the risk of MACCEs and it is recommended to monitor the AIP for lipid management in patients with established T2DM and CHD.
Study context
- Population
- Patients with T2D and coronary heart disease, China-Japan Friendship Hospital, January 2019–March 2022
- Participants
- 1,034 patients
- Exposure
- Triglyceride (TG)-derived metabolic indices and major adverse cardiac and cerebrovascular events (MACCEs)
- Outcome
- Major adverse cardiac and cerebrovascular events (MACCEs)
- Follow-up
- Median 13.3 months
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
MACCEs · median 13.3 months
- Overall incidence of MACCEs
- 31.04%
- Atherogenic index of plasma (AIP), triglyceride-glucose (TyG) index and triglyceride glucose-body mass index (TyG-BMI) all positively correlated with risk of MACCEs
- P < 0.05
- AIP had the strongest ability to predict MACCEs (AUC)
- 0.899
- Highest AIP values increased risk of MACCEs
- 83.5%
- AIP nonlinearly associated with cardiovascular outcomes (restricted cubic spline (RCS))
- P for nonlinear = 0.0118
- Cumulative incidence of MACCEs significantly higher with higher AIP tertiles
- all Log rank P < 0.001
Observational data: associations, not effects.
Further findings
Calibration of multivariate model
- Excellent goodness-of-fit (χ2 = 13.210)
- P = 0.105
Subgroup analysis
- Positive association of AIP with cardiovascular risk similar across subgroups except non-hypertensive individuals
Original publication
Multiple triglyceride-derived metabolic indices and incident cardiovascular outcomes in patients with type 2 diabetes and coronary heart disease. Cardiovasc Diabetol. Published 14 October 2024. doi:10.
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