Sleep Irregularity and the Incidence of Type 2 Diabetes: A Device-Based Prospective Study in Adults
Authors' conclusion
Moderate and high sleep irregularity were deleteriously associated with T2D risk, even in participants who slept ≥7 h per night. Future sleep interventions will need to pay more attention to consistency in bedtimes and wake-up times, in addition to sleep duration and quality.
Study context
- Population
- Adults aged 40–79 years without a history of T2D, UK Biobank accelerometer substudy; 7-day wrist accelerometry
- Participants
- 73,630 adults
- Exposure
- Irregular and moderately irregular vs regular sleepers
- Outcome
- Incident T2D (self-reports and health records)
- Follow-up
- 8 years
Methodological detailspopulation-based, device-based (wrist accelerometer)
- Population-based
- Device-based (wrist accelerometer)
Main finding
As reported in the abstract
Incident T2D
Each group vs regularHazard ratio (95% CI)
Irregular
1.38(1.20–1.59)
Moderately irregular
1.35(1.19–1.53)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Incident T2D in participants meeting sleep duration recommendationsIrregularvs Regular | 1.35 (1.09–1.66) | |
| Incident T2D in participants meeting sleep duration recommendationsModerately irregularvs Regular | 1.29 (1.08–1.54) | |
| 0.512Hazard ratio (log scale) |
Dose-response, Sleep Regularity Index (SRI) as continuous measure
- Higher T2D incidence with SRI scores <80
Original publication
Sleep Irregularity and the Incidence of Type 2 Diabetes: A Device-Based Prospective Study in Adults. Diabetes Care. Published 10 October 2024. doi:10.
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