Cardiovascular prognosis in patients with type 2 diabetes mellitus mediated by the functional completeness after revascularization
Authors' conclusion
The degree of functional revascularization may emerge as a central mechanism pivotal in elucidating the association between T2DM and the risk of MACE. Cardiologists should prioritize functional complete revascularization during the initial PCI procedure for patients with diabetes mellitus.
Study context
- Population
- Patients after percutaneous coronary intervention (PCI) with available post-PCI quantitative flow ratio (QFR), PANDA III trial
- Participants
- 1,555 patients
- Comparison
- T2DM vs no T2DM; mediation by functional complete revascularization
- Primary endpoint
- MACE: all-cause death, all MI, or any ischemia-driven revascularization
- Follow-up
- 2 years
Methodological detailsmediation analysis, structural equation modeling
- Mediation analysis
- Structural equation modeling
Primary result
As reported in the abstract
MACE
- T2DM associated with MACE (multiple Cox regression)
- P=0.007
- T2DM vs MACE after adding functional complete revascularization (CR) to the model
- P=0.05
- Indirect effect of T2DM on MACE through functional CR (partial mediation)
- P=0.006, Mediated [%] = 27.3
Original publication
Cardiovascular prognosis in patients with type 2 diabetes mellitus mediated by the functional completeness after revascularization. Diabetes Res Clin Pract. Published 10 October 2024. doi:10.
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