Triglyceride-glucose index is associated with recurrent revascularization in patients with type 2 diabetes mellitus after percutaneous coronary intervention
Authors' conclusion
The findings highlight the potential of the TyG index as a predictor of recurrent revascularization. Lesion progression emerged as the primary contributor to recurrent revascularization instead of in-stent restenosis. The incorporation of the TyG index into risk prediction models is likely to be beneficial for accurate risk stratification in order to improve prognosis.
Study context
- Population
- Patients with T2DM after percutaneous coronary intervention (PCI)
- Participants
- 633 patients
- Exposure
- Triglyceride-glucose (TyG) index tertiles
- Outcome
- Recurrent revascularization resulting from progression of lesions or in-stent restenosis (ISR); all-cause death as competing risk
- Follow-up
- Median 18.33 months
Methodological detailscompeting risk analysis, internal bootstrap validation (1000 resamples)
- Competing risk analysis
- Internal bootstrap validation (1000 resamples)
Main finding
As reported in the abstract
Patients with recurrent revascularization
64
10.11%
Lesion progression cases
55
In-stent restenosis cases
9
TyG index (standardized) subdistribution hazard ratio (SHR) for recurrent revascularization, after controlling for competing risk; 95% CI 1.1458-1.7959; P = 0.002
1.4345
Observational data: associations, not effects.
Further findings
Incremental predictive value of TyG index added to established risk model
- C-index
- 0.759 (95% CI 0.724-0.792, P < 0.01)
- cNRI > 0
- 0.170 (95% CI 0.023-0.287, P < 0.05)
- Integrated discrimination improvement (IDI)
- 0.024 (95% CI 0.009-0.039, P = 0.002)
- Likelihood ratio test and Akaike's information criteria: TyG index significantly improves prognostic ability
- Results consistent on internal bootstrap validation
Original publication
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