Triglyceride-glucose index as a suitable non-insulin-based insulin resistance marker to predict cardiovascular events in patients undergoing complex coronary artery intervention: a large-scale cohort study
Authors' conclusion
The TyG index, not TG/HDL-C ratio and METS-IR, was positively associated with worse CV outcomes in patients undergoing complex PCI. Our study, for the first time, demonstrated that the TyG index can serve as the suitable non-insulin-based IR marker to help in risk stratification and prognosis in this population.
Study context
- Population
- Patients undergoing complex percutaneous coronary intervention (PCI) at Fuwai Hospital, January 2017 to December 2018consecutively enrolled
- Participants
- 9,514 patients
- Exposure
- Triglyceride-glucose (TyG) index vs TG/HDL-C ratio vs metabolic score for insulin resistance (METS-IR) as non-insulin-based insulin resistance (IR) markers
- Outcome
- CV events: composite of CV death, nonfatal MI and nonfatal stroke
- Follow-up
- Median 3.1 years
Methodological detailsdescriptive, consecutively enrolled, single-centre
- Descriptive
- Consecutively enrolled
- Single-centre
Main finding
As reported in the abstract
CV events:
- Multivariable Cox regression
- Per-unit increase
| Group | HR |
|---|---|
| TyG index | 1.42 (95% CI 1.13-1.77) |
| Ln(TG/HDL-C ratio) | 1.18 (95% CI 0.96-1.45) |
| METS-IR | 1.00 (95% CI 0.98-1.02) |
HR
TyG index1.42 (95% CI 1.13-1.77)
Ln(TG/HDL-C ratio)1.18 (95% CI 0.96-1.45)
METS-IR1.00 (95% CI 0.98-1.02)
- Cardiovascular (CV) events occurred
- 324 (3.5%)
Observational data: associations, not effects.
Further findings
Incremental prognostic value of adding TyG index to original model
- C-statistic, original model vs with TyG index
- 0.618 vs. 0.627, P < 0.001
- NRI
- 0.12, P = 0.031
- IDI
- 0.14%, P = 0.003
- No significant improvement adding Ln(TG/HDL-C ratio) or METS-IR
- both P > 0.05
Original publication
Triglyceride-glucose index as a suitable non-insulin-based insulin resistance marker to predict cardiovascular events in patients undergoing complex coronary artery intervention: a large-scale cohort study. Cardiovasc Diabetol. Published 6 January 2024. doi:10.
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