Modifiable Lifestyle Factors, Genetic Risk, and Incident Peripheral Artery Disease Among Individuals With Type 2 Diabetes: A Prospective Study
Main finding · Incident PADResult — go to the resultHazard ratio 0.27 95% CI 0.19–0.38Authors' conclusion
A favorable lifestyle was associated with lower risk of PAD among individuals with T2D, independent of genetic predisposition to PAD.
Study context
- Population
- Individuals with T2D from the UK Biobank628 incident peripheral artery disease (PAD) cases
- Participants
- 14,543 individuals
- Exposure
- Favorable vs intermediate vs unfavorable lifestyle
- Outcome
- Incident PAD
- Follow-up
- Median 13.5 years
Methodological detailsUK Biobank, genetic risk score stratification
- UK Biobank
- Genetic risk score stratification
Main finding
As reported in the abstract
median 13.5 years
Hazard ratio
0.27
95% CI 0.19–0.38
P < 0.0001 for trend
Favorablevs Unfavorable
HR 0.27 (95% CI 0.19–0.38); P for trend < 0.0001
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| PAD GRS and PAD risk | 1.13 (1.03–1.23) | |
| 0.512Hazard ratio (log scale) |
PAD potentially avoidable if all attained favorable lifestyle
- Population attributable fraction
- 58.3% (95% CI 45.0%, 69.1%)
PAD genetic risk score (GRS) and PAD risk
- Favorable lifestyle partially mitigated excess PAD risk with higher GRS; interaction nonsignificant
Mediation by biomarkers (lipid metabolism, hepatic/renal function, systemic inflammation)
- Proportion of lifestyle–PAD association explained
- 13.3% (95% CI 8.5%, 20.1%)
Original publication
Modifiable Lifestyle Factors, Genetic Risk, and Incident Peripheral Artery Disease Among Individuals With Type 2 Diabetes: A Prospective Study. Diabetes Care. Published 5 January 2024. doi:10.
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