Leisure-Time Physical Activity May Attenuate the Impact of Diabetes on Cognitive Decline in Middle-Aged and Older Adults: Findings From the ELSA-Brasil Study
Authors' conclusion
In adults living with diabetes, LTPA attenuated the deleterious association between diabetes and cognitive function.
Study context
- Population
- Middle-aged and older adults (age 35–74 years) in the ELSA-Brasil cohort, enrolled 2008–2010; mean age 51.4 (SD 8.8) years, 55.5% womencohort of 15,105
- Participants
- 12,214 participants
- Exposure
- Physically active vs inactive, in adults with and without diabetes
- Inactiven = 9,345
- Diabetesn = 1,731
- Outcome
- Global cognition change (sum of six standardized tests of memory and verbal fluency, including the Trail-Making Test); incident cognitive impairment (follow-up score lower than −1 SD from baseline mean)
- Follow-up
- Mean 8.1 (SD 0.6) years
Methodological detailsmultivariable regression models
- Multivariable regression models
Main finding
As reported in the abstract
Risk of cognitive impairment with diabetes, by LTPA
Diabetes vs Without diabetesHazard ratio (95% CI)
In inactive adults
1.71(1.22–2.39)
In active adults
1.18(0.73–1.90)
- Among participants with diabetes, active participants showed a delay in onset of cognitive impairment
- 2.73 years (95% CI 0.94, 4.51)
Observational data: associations, not effects.
Further findings
Decline in global cognition · mean follow-up 8.1 (SD 0.6) years
- Inactive participants had faster decline in global cognition than active (β)
- −0.003, −0.004, and −0.002
- Participants with diabetes had faster decline in global cognition than those without diabetes (β)
- −0.004, −0.005, and −0.003
Original publication
Leisure-Time Physical Activity May Attenuate the Impact of Diabetes on Cognitive Decline in Middle-Aged and Older Adults: Findings From the ELSA-Brasil Study. Diabetes Care. Published 5 January 2024. doi:10.
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