Glycemic control and cardiovascular outcomes in patients with diabetes and coronary artery disease according to triglyceride-glucose index: a large-scale cohort study
Authors' conclusion
Controlled glycemia was associated with improved CV outcomes in patients with diabetes and established CAD, especially in those with high TyG index levels. Our study, for the first time, provided valuable information that TyG index could help making risk stratification on the glycemic management in diabetic patients with CAD.
Study context
- Population
- Diabetic patients with angiograph-proven coronary artery disease (CAD), consecutively recruited 2017–2018 at Fuwai Hospital
- Participants
- 9,996 patients
- Exposure
- Controlled vs uncontrolled glycaemia, stratified by triglyceride-glucose (TyG) index tertile
- Outcome
- CV events: CV death, nonfatal MI and nonfatal stroke
- Follow-up
- median 3-year follow-up
Methodological detailssingle-centre, consecutive recruitment, multivariable adjusted
- Single-centre
- Consecutive recruitment
- Multivariable adjusted
Main finding
As reported in the abstract
CV events, controlled glycaemia (HbA1c <7%) by TyG index subgroup
Hazard ratio (95% CI)
T3 vs T1controlled glycaemiavs not, within T3; fully adjusted
0.64(0.42–0.96)
T1controlled glycaemiavs not, within T1; fully adjusted
0.79(0.53–1.16)
T2 vs T1controlled glycaemiavs not, within T2; fully adjusted
0.84(0.56–1.25)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| CV events, TyG index T3vs T1 · median 3-year follow-upMultivariable adjusted | 1.40 (1.02–1.94) | |
| 0.512Hazard ratio (log scale) |
CV events, overall · median 3-year follow-up
- CV events occurred
- 381 (3.8%)
Original publication
Glycemic control and cardiovascular outcomes in patients with diabetes and coronary artery disease according to triglyceride-glucose index: a large-scale cohort study. Cardiovasc Diabetol. Published 6 January 2024. doi:10.
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