Effects of percutaneous coronary intervention and diabetes mellitus on short- and long-term prognosis assessed by the three-vessel quantitative flow ratio
Authors' conclusion
In the short term, a low post-PCI 3 V-QFR is a predictor of high risk for MACE. However, in the long term, DM emerges as the dominant risk factor.
Study context
- Population
- Patients with coronary artery disease who underwent percutaneous coronary intervention (PCI), assessed by 3V-QFR
- Participants
- 1,181 patients2,440 vessels
- Exposure
- Diabetes mellitus (DM) vs no DM, by post-PCI 3V-QFR above vs below median
- Outcome
- MACE: composite of cardiovascular death, MI and ischemia-driven revascularization
- Follow-up
- 5 years
Methodological detailslandmark analysis
- Landmark analysis
Main finding
As reported in the abstract
MACE
- Major adverse cardiac events (MACE) comparable among all groups within first year (log-rank p = 0.088)
- Over 2 years, MACE higher in both groups with post-PCI 3V-QFR <2.94 (log-rank p < 0.001)
- From 2 to 5 years, MACE higher with DM (log-rank p = 0.013)
- Landmark analysis
Observational data: associations, not effects.
Further findings
3V-QFR, entire population
- Pre-PCI 3V-QFR
- 2.37 (2.04-2.56)
- Post-PCI 3V-QFR
- 2.94 (2.82-3.00)
Original publication
Effects of percutaneous coronary intervention and diabetes mellitus on short- and long-term prognosis assessed by the three-vessel quantitative flow ratio. Diabetes Res Clin Pract. Published 14 November 2023. doi:10.
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