Non‐alcoholic fatty liver disease is associated with brain function disruption in type 2 diabetes patients without cognitive impairment
Authors' conclusion
This study may provide novel insights into neuroimaging correlates for underlying pathophysiological processes inducing brain damage in T2NAFLD. Thus, controlling blood glucose levels, lipid levels and abdominal obesity may reduce brain damage risk in such patients.
Study context
- Population
- Patients with T2D with or without non-alcoholic fatty liver disease (NAFLD) and healthy controls, all with normal cognitionnormal cognition
- Participants
- 56 / 78 / 55
- Exposure
- T2D with NAFLD vs T2D without NAFLD vs healthy controls
- T2NAFLDn = 56
- T2noNAFLDn = 78
- Healthy controls (HCs)n = 55reference
- Outcome
- Static and dynamic intrinsic activity of intra-/inter-network topology on functional MRI, and relationship with metabolism
Main finding
As reported in the abstract
Brain function (intra-/inter-network topology)
- T2NAFLD had more disordered glucose and lipid metabolism, more severe insulin resistance and more obesity than T2noNAFLD
- T2D patients had disrupted brain function (altered intra-/inter-network topology) even without clinically measurable cognitive impairment
- T2NAFLD had greater reductions in frequency spectrum parameters of cognitive executive and visual networks than T2noNAFLD
- Altered brain function in T2D correlated with postprandial glucose, HDL-C and WHR
- P < 0.05, false discovery rate-corrected
Observational data: associations, not effects.
Original publication
Non‐alcoholic fatty liver disease is associated with brain function disruption in type 2 diabetes patients without cognitive impairment. Diabetes Obes Metab. Published 14 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →