Chronic Insufficient Sleep in Women Impairs Insulin Sensitivity Independent of Adiposity Changes: Results of a Randomized Trial
Authors' conclusion
Curtailing sleep duration to 6.2 h/night, reflecting the median sleep duration of U.S. adults with short sleep, for 6 weeks impairs insulin sensitivity, independent of adiposity. Findings highlight insufficient sleep as a modifiable risk factor for insulin resistance in women to be targeted in diabetes prevention efforts.
Study context
- Population
- Women aged 20–75 years without cardiometabolic diseases, actigraphy-confirmed habitual total sleep time 7–9 h/night11 postmenopausal
- Participants
- 38 women
- Comparison
- 1.5 h/night sleep restriction vs adequate sleep
Methodological detailstwo 6-week phases
- Two 6-week phases
Primary result
As reported in the abstract
6 weeks
β
6.8 pmol/L
P = 0.016
fasting insulin; ±SEM 2.8; adjusted for baseline
β
0.30
P = 0.016
HOMA of insulin resistance (HOMA-IR); ±SEM 0.12; adjusted for baseline
Further findings
| Outcome | Reduction (h/night) | P value |
|---|---|---|
| Total sleep timeReduced with SR; ±SEM 0.04 | 1.34 | P < 0.0001 |
HOMA-IR effect of sleep restriction (SR) vs adequate sleep (AS) by menopausal status
- Postmenopausal β
- 0.45 ± 0.25
- Premenopausal β
- 0.27 ± 0.13
- P for interaction
- 0.042
Adiposity
- Change in adiposity did not mediate SR effects on glucose metabolism or change results as a covariate
Original publication
Chronic Insufficient Sleep in Women Impairs Insulin Sensitivity Independent of Adiposity Changes: Results of a Randomized Trial. Diabetes Care. Published 13 November 2023. doi:10.
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